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. 2014 Feb 3;9(2):e87941. doi: 10.1371/journal.pone.0087941

Figure 4. Female PERαKO−/− mice are susceptible to ALX-induced diabetes.

Figure 4

(A) Random-fed blood glucose from day 0 to day 11 after injection of either 150 mg/Kg of ALX or saline. (B) Corresponding area under the curve (AUC) for glucose. (C) Ratio of random-fed of insulin (ng/ml) and glucose (mg/dl) at day 11 was used as an index of insulin deficiency. (D) Representative sections showing immunofluorescent histochemical analysis of pancreas sections stained for insulin (green) and glucagon (red) in control ERαlox+/+ and PERαKO−/− mice (E) β-cell mass quantification. (F) Pancreas insulin concentration 11 day after ALX injection. Values represent the mean±SEM, n = 4–13/group. *P<0.05, **P<0.001 ***P<0.01, Bar represents 100 µm.