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A, Original and modified TALEN structures. TAL-A and TAL-B contain truncated N-terminal (+141) and C-terminal (+63) TALE domains (ΔNΔC), and TAL-A also contains a mutated FokI, Sharkey, instead of the wild type. TALE-N, N-terminal TALE domain; TALE-C, C-terminal TALE domain; HA, hemagglutinin tag; NLS, nuclear localization signal. The amino acid sequences of these TALEN scaffolds and their numbering are shown in Figure S1.
