Table 1.

A number of processes can affect mitochondrial redox signaling and subsequent alteration of cancer invasiveness. Intra-tumoral hypoxia is a major driving force in orchestrating the invasive attributes of tumor cells. It is thus expected that hyperoxia would have the opposite effect. Hypoxia is associated with more dependence on glycolysis for energy in contrast to OXPHOS. A high metabolic rate by the host suppresses invasiveness by attenuating hypoxia in the tumor microenvironment

Process	Mittochondrial site	Effect on Invasiveness
Hypoxia	Tumor cells	Enhancement
OXPHOS	Tumor cells	Suppression
Glycolisis	Tumor cells	Enhancement
High metabolic rate	Host microenvironment	Suppression
Hypoxia	Tumor cells and microenvironment	Suppression