Effect of geometry on mechanical behavior of culture wells under compression. (A) Lateral stresses generated perpendicular to applied compressive strains of 15% in deep (0.5 mm thick base), medium (5 mm thick base) and shallow (9.5 mm thick base) wells. (B) Out-of-plane deflection of the wells resulting from applied compression. (C) Lateral stresses and (D) out-of-plane deflection across the center of the wells (centered at origin x = 0, y = 0) demonstrate an increase in stress uniformity and decrease in magnitude of out-of-plane displacement with decreasing well depth. Compressive stress, tensile stress, and deflection are reported along the y-axis, x-axis, and z-axis respectively.