Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Dec 15;139(24):4514–4523. doi: 10.1242/dev.083279

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

PMC Copyright notice

Fig. 6. — LIN28 depletion after fertilization results in a developmental arrest. (A,B) A significant number of Lin28A-MO-injected embryos arrest at the 2- or 4-cell stage after 48 hours of in vitro culture in comparison with controls (P<0.001). Lin28A-MO-injected embryos never develop to morula or blastocyst stage after 96 hours of in vitro culture, unlike the majority of control embryos. Error bars represent mean ± s.e.m. from at least three independent sets of experiments. (C) Immunostaining confirmed that nucleolar LIN28 expression is absent in Lin28A-MO-injected embryos, arrested at the 4-cell stage, but present in Control-MO-injected and uninjected embryos. DNA was counterstained with propidium iodide. Scale bar: 20 μm.

HHS Vulnerability Disclosure