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. 2012 Dec 15;139(24):4514–4523. doi: 10.1242/dev.083279

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 7. — NPM expression and chromocenter formation following LIN28 depletion. Confocal immunofluorescence analysis of NPM (green) and HP1 (red) in whole-mount embryos. DNA was counterstained with DAPI. (Ad-f) Different optical slices illustrate that NPM is distributed throughout the nucleoplasm and is not enriched at the periphery of presumptive NPBs in 2-cell arrested embryos. (Aj-l) In control late 2-cell embryos, NPM is enriched at the periphery of NPBs. (Aa-c,g-i) Heterochromatin and chromocenter clustering is brightly stained by DAPI (arrow). Heterochromatic foci are outside (Aa,b,g) or in association (Ac,h) with NPBs (arrow). (Ba-c′) Chromocenters were strongly enriched in HP1. An enlarged view of a single optical slice shows that HP1 (red) colocalizes with condensed DNA (arrow) in 2-cell arrested (Ba-c) and control (Ba′-c′) embryos. Scale bar: 20 μm.

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