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PC-3 cell chemoinvasion in the presence of CTCE-9908. Chemonivasion of PC-3 cells were performed with Matrigel-coated inserts. PC-3 cells were pretreated with 1 and 50 μg/ml of CTCE-9908 for 48 hours then seeded in chemoinvasion inserts and exposed to CTCE-9908. 200 ng/ml of CXCL12 was added to the lower chamber as a chemoattractant. Invaded cells at the bottom of the filter were quantitated and shown in figure.
