Table 3.
Interference from Common Hemoglobin Variants on A1c Measurements from Commonly Used Methods24
| Method | Interference from HbC | Interference from HbS | Interference from HbE | Interference from HbD |
|---|---|---|---|---|
| Abbott Architect/Aeroset | Yes | Yes | * | * |
| Arkray ADAMS A1c HA-8180V (Menarini) | No | No | A1c not quantified | A1c not quantified |
| Axis-Shield Afinion | No | No | No | No |
| Bayer A1cNOW | Yes | Yes | No | No |
| Beckman AU system | Yes | Yes | No | No |
| Beckman Synchron System | No | No | No | No |
| Bio-Rad D-10 (A1c program) | No | No | No | No |
| Bio-Rad Variant II NU | – | – | No | No |
| Bio-Rad Variant II Turbo | No | No | Yes | Yes |
| Bio-Rad Variant II Turbo 2.0 | No | No | No/Yes (conflicting reports) | No |
| Bio-Rad in2it | Yes | No | Yes | No |
| Ortho-Clinical Vitros | No | No | No | No |
| Roche Cobas Integra Gen.2 | No | No | No | No |
| Roche/Hitachi (Tina Quant II) | No | No | No | No |
| Sebia Capillarys 2 Flex Piercing | No | No | No | No |
| Siemens Advia HbA1c (original version) | Yes | Yes | * | * |
| Siemens Advia A1c (new version) | No | No | * | * |
| Siemens DCA 2000 | No | No | No | No |
| Siemens Dimension | No | No | No | No |
| Tosoh G7 | Yes | No | Yes | No |
| Tosoh G8 | No | No | Yes | No |
| Trinity (Primus) HPLC (affinity) | No | No | No | No |
* Generally assumed there is no interference
Adapted with permission from: HbA1c assay interferences. National Glycohemoglobin Standardization Program Web site. Available at: http://www.ngsp.org/interf.asp. Updated August, 2012. Accessed November 8, 2012