Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nat Med. 2013 Dec 15;20(1):54–61. doi: 10.1038/nm.3423

Figure 1. High fat diet feeding induces AHR in wildtype mice.

Figure 1

(a–c). Wild type mice fed normal chow or 60% HFD, starting at weaning for 12–14 weeks.

a. Comparison of bodyweight gain in wild-type C57BL/6 mice on normal chow or the HFD. ***p<0.001, HFD group compared to chow fed group. (Student’s t-test)

b. Representative picture of mice and organs after chow or HFD feeding. Scale bar indicates 5mm

c. Wild-type mice develop AHR, as assessed by the response to increasing doses of methacholine. Results represent the changes in lung resistance (RL) as a measure of AHR. **p<0.01, and ***p<0.001, compared to chow fed group. (Two-way ANOVA).

Data are representative of at least three independent experiments. Error bars represent SEM.

d. 7 wks old ob/ob mice fed on normal chow diet develop AHR. Results represent the changes in lung resistance (RL) as a measure of AHR. *p<0.05, and **p<0.01, compared to wild type mice. (Two-way ANOVA).