Table 1. Discovery cohort association analyses of 17 NOS2 SNPs with VEO-IBD.
Recessive association |
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Chr. | SNP | Position | MAF | FU | FA | P-value | OR | L95 | U95 |
17 | rs2297518 | 23120724 | 0.18 | 0.23 | 0.17 | 6.2 × 10−6 | 4.43 | 2.32 | 8.46 |
17 | rs1137933 | 23130059 | 0.21 | 0.27 | 0.21 | 7.4 × 10−4 | 2.64 | 1.50 | 4.65 |
17 | rs9906835 | 23113501 | 0.42 | 0.38 | 0.43 | 0.39 | 0.81 | 0.51 | 1.29 |
17 | rs944725 | 23133698 | 0.41 | 0.50 | 0.40 | 0.03 | 1.56 | 1.03 | 2.34 |
17 | rs3730013 | 23150045 | 0.34 | 0.29 | 0.34 | 0.19 | 0.67 | 0.36 | 1.22 |
17 | rs4795067 | 23130802 | 0.33 | 0.35 | 0.33 | 0.08 | 1.48 | 0.94 | 2.33 |
17 | rs2297516 | 23119857 | 0.42 | 0.38 | 0.42 | 0.91 | 1.02 | 0.66 | 1.58 |
17 | rs3794764 | 23135555 | 0.23 | 0.21 | 0.23 | 0.71 | 0.86 | 0.40 | 1.86 |
17 | rs8072199 | 23140975 | 0.44 | 0.51 | 0.44 | 0.482 | 1.16 | 0.76 | 1.75 |
17 | rs10459953 | 23151645 | 0.35 | 0.33 | 0.35 | 0.93 | 1.02 | 0.61 | 1.65 |
17 | rs2314809 | 23119505 | 0.40 | 0.36 | 0.40 | 0.92 | 0.97 | 0.62 | 1.53 |
17 | rs11080344 | 23128638 | 0.46 | 0.44 | 0.46 | 0.09 | 1.39 | 0.94 | 2.05 |
17 | rs3794756 | 23110756 | 0.01 | 0.02 | 0.01 | NA | NA | NA | NA |
17 | rs3729508 | 23133157 | 0.40 | 0.38 | 0.40 | 0.96 | 1.01 | 0.64 | 1.58 |
17 | rs11653716 | 23108659 | 0.032 | 0.05 | 0.03 | NA | NA | NA | NA |
17 | rs2314810 | 23128237 | 0.04 | 0.04 | 0.04 | 0.56 | 1.93 | 0.19 | 18.71 |
17 | rs3730017 | 23133229 | 0.020 | 0.02 | 0.02 | NA | NA | NA | NA |
FA, frequency affected; FU, frequency unaffected; L95 and U95, lower and upper 95th confidence interval; MAF, minor allelic frequency.
P values are presented as uncorrected and recessive modeling.