Fig 5.

Statistical models demonstrating the ability of age threshold alone to enrich selection for renal cell carcinoma (RCC) genetic counseling germline mutation testing. (A) Receiver operating characteristic curve of sensitivity versus 100%−specificity, considering age threshold testing at the 2.5th, 10th, 25th, and 50th percentiles. For this analysis, a 1% incidence of hereditary RCC was used. (B) Number needed to test approximated on the basis of various estimates of the incidence of hereditary, monogenic RCC syndrome.