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. 2014 Feb 4;5:36. doi: 10.3389/fphys.2014.00036

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Copyright © 2014 Otsu, Kumakami-Sakano, Fujiwara, Kikuchi, Keller, Lesot and Harada.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Odontogenic response of NCLCs derived from iPS cells to dental epithelium. (A) Image showing appearance of the recombinant between NCLCs and dental epithelium 2 weeks after transplantation under the kidney capsule. Bar = 500 μm. (B) Histological section of the recombinant showing tooth-like structure. Bar = 200 μm. Cells inside the dentin-like structure were positive for odontoblast markers DSP (C, Bar = 10 μm) and nestin (D, Bar = 25 μm).