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. 2014 Feb 4;7:2. doi: 10.3389/fnmol.2014.00002

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Copyright © 2014 Bhatnagar, Chertkow, Schipper, Yuan, Shetty, Jenkins, Jones and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between expression levels of miR-34c and miR-34a in plasma with Mini-Mental Status Examination (MMSE) scores in selected samples of age-matched groups. (A) Plasma expression levels of miR-34c represented by inverse ΔCt, plotted against corresponding MMSE scores. A high Pearson correlation coefficient value of −0.72 indicates a strong correlation between MMSE scores and 1/deltaCt values, P < 0.0001. (B) Expression levels of miR-34a in plasma of AD and NEC individuals represented by inverse ΔCt, plotted against corresponding MMSE scores. A low Pearson correlation coefficient value of −0.34 indicates a weak correlation between the MMSE scores and 1/deltaCt values, P = 0.012. Data points of Mini-Mental Status Examination (MMSE) score are shown as follows: () moderate AD (score 10–20), () mild AD (score 21–24), and () NEC (score 25–30).