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. 2014 Feb;24(2):349–355. doi: 10.1101/gr.163832.113

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© 2014 Santoni et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 2. — Extraction of de novo mutations from the CEU trio. Precisions obtained by VariantMaster, KGGSeq, and PolyMutt + KGGSeq, as functions of increasing quality score thresholds, have been plotted. Losses of true de novo variants have been emphasized with color-matching arrows. Precisions obtained by VariantMaster with a reduction to 25% coverage (∼10×) in the unaffected individuals are shown in green.