Figure 7.
A) Crystallographic structure of DB1880-DNA complex, which is displayed as space filling type. The DNA sequence is shown in grey, DB1880 molecule in magenta, nitrogen atoms in blue and oxygen atoms in red. B) The full sequence with bases numbered and binding schematic. Detailed views of the hydrogen-bond interactions between the DB1880 ligand and the DNA. The distances were measured between heavy atoms and are in Å. C) Showing the three hydrogen bonds between one amidinium nitrogen atom and the O4′ atom of Thy20, and the O2 atoms of Thy20 and Thy19. D) Showing the hydrogen bonds between amidinium nitrogen atoms and the O2 atom of Cyt9, and the O4′ atoms of Cyt9 and Ade18. E) Showing the network of hydrogen bonds bridging water molecules with DB1880 and DNA phosphate oxygen atoms.