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. Author manuscript; available in PMC: 2014 Feb 4.
Published in final edited form as: Clin Cancer Res. 2012 Jan 18;18(5):1227–1236. doi: 10.1158/1078-0432.CCR-11-2308

Figure 1. Histology and immunohistochemistry of MCC.

Figure 1

(A) H&E staining illustrating a population of monomorphic, non-cohesive round cells with a high nuclear to cytoplasmic ratio and finely granular “salt and pepper” chromatin. (B) Positive staining for the neuroendocrine marker synaptophysin. (C) cytokeratin 20 dot-like perinuclear staining. Additional features observed in some tumors: (D) spindle morphology (arrows), (E) large zone of necrosis, and (F) prominent nucleoli (arrows). Scale bar: 50 micron.