Table 2.
Pathology of MCC cases.
| All Patients n=60 |
PIK3CA Mutational Status | MCPyV Status* | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Positive n=7 | Negative n=53 | P value | Positive n=38 | Negative n=20 | P value | ||
| No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | |||
| Specimen size, cm | <0.001 | 0.120 | |||||
| Median | 2.2 | 8.0 | 2.0 | 2.00 | 3.65 | ||
| Range | 0.5-12.5 | 3.5-12.5 | 0.5-8.0 | 0.5-8.0 | 0.5-12.5 | ||
|
| |||||||
| Specimen size | 0.070 | 0.239 | |||||
| < 2cm | 21 (35) | 0 (0) | 21 (40) | 16 (42) | 5 (25) | ||
| 2-12.5cm | 31 (52) | 6 (86) | 25 (47) | 18 (47) | 13 (65) | ||
| unknown | 8 (13) | 1 (14) | 7 (13) | 4 (11) | 2 (10) | ||
|
| |||||||
| % Necrosis | 0.053 | 0.010 | |||||
| Median | 0% | 20% | 0% | 0% | 5% | ||
| Range | 0-95% | 0-60% | 0-95% | 0-95% | 0-60% | ||
|
| |||||||
| Necrosis | 0.095 | 0.004 | |||||
| 0% | 37 (62) | 2 (29) | 35 (66) | 29 (76) | 7 (35) | ||
| 5-95% | 23 (38) | 5 (71) | 18 (34) | 9 (24) | 13 (65) | ||
|
| |||||||
| Nucleoli visible | 0.663 | 0.373 | |||||
| Negative | 42 (70) | 6 (86) | 36 (68) | 28 (74) | 12 (60) | ||
| Positive | 18 (30) | 1 (14) | 17 (32) | 10 (26) | 8 (40) | ||
|
| |||||||
| Spindle Shape | 0.099 | 0.044 | |||||
| Negative | 55 (92) | 5 (71) | 50 (94) | 37 (97) | 16 (80) | ||
| Positive/Pleomor. | 5 (8) | 2 (29) | 3 (6) | 1 (3) | 4 (20) | ||
|
| |||||||
| Vascular Invasion | 0.101 | 0.195 | |||||
| Absent | 31 (52) | 1 (14) | 30 (32) | 23 (61) | 7 (35) | ||
| Present | 8 (13) | 2 (29) | 6 (57) | 4 (11) | 4 (20) | ||
| unknown | 21 (35) | 4 (57) | 17 (11) | 11 (29) | 9 (45) | ||
*
due to limited amount of tumor, we were unable to determine MCPyV status for two cases