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. 2014 Feb 3;204(3):331–342. doi: 10.1083/jcb.201310136

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© 2014 Iijima et al.

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Figure 7. — Cell type–specific alternative splicing of SLM1. (A) Shift in alternative splicing at Nrxn1, Nrxn2, and Nrxn3 AS4 in cerebellar granule cells expressing SLM1 ectopically with lentiviral infection. Expression of 2A-tagged SLM1 in lentivirus-infected cerebellar granule cells was confirmed by immunostaining with anti-2A antibody. Representative images of semi-quantitative RT-PCR with Nrxn AS4 in granule neurons with or without ectopic SLM1 expression. (B) High magnification views of SLM1 immunoreactivity in Purkinje cell–specific Slm1^KO (Slm1^cKO) mice. Purkinje cells are marked by transgenic expression of EGFP from the Purkinje cell–specific L7 promoter. Bar, 50 µm. (C) Representative images of semi-quantitative RT-PCR with Nrxn AS4 in cerebellum from wild-type, Slm1^KO, and Slm1^cKO mice. (D) Quantitative RT-PCR for Nrxn1 and Nrxn2 AS4 in wild-type, Slm1^KO, and Slm1^cKO mice (n = 4 animals per genotype).