Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 3;204(3):423–441. doi: 10.1083/jcb.201308028

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Rouvinski et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 10. — Models. (A, a) Map of PrP^Sc metabolism and trafficking in infected cells. FL PrP^Sc is formed on rafts either on the cell surface or in an endocytic compartment. FL PrP^Sc is then N-proximally truncated into PrP27-30 by acidic proteases and accumulates in endolysosomes. (b) Strings acquire PrP^Sc either by converting cell surface PrP^C (alternative i) or by importing it from intracellular conversion compartments (ii). PrP27-30 is probably recycled from hydrolytic endosomes (dashed arrows). However, PrP27-30 could also be generated by in-string truncation on the cell surface. (c) Whereas PrP^C is rapidly endocytosed in subconfluent GT1, PrP^Sc is delayed in cell surface strings for >4 h. (B) Models of string structure. (Model A) Strings are amyloid fibrils/ribbons anchored to the cell surface. (Model B) Strings are composed of PrP^Sc foci aligned by yet unknown cellular structures (e.g., ECM or membrane elements; see Discussion).