TABLE 2.
Effects of the soluble epoxide hydrolase inhibitor AUDA on EETs and DHETs in liver after treatment with TCDD or TCDD + AUDA for 6 hours
For EETs, P values (T+AUDA vs. T alone) are given in parentheses.a n = 3 individual livers for each treatment group. T, TCDD.
| EETs | Ratio EET/DHET | Fold Change in the Ratio EET/DHET T + AUDA vs. T | |||
|---|---|---|---|---|---|
| T | T + AUDA | T | T + AUDA | ||
| mean ng/g liver ± S.E. | mean ± S.E. | ||||
| 5,6- | 76.6 ± 13.5 | 141.8 ± 32.2 (P = 0.06) | 24.1 ± 4.3 | 75 ± 17 | 3.1 (P = 0.044) |
| 8,9- | 2.0 ± 0.1 | 14.4 ± 5.6 (P = 0.04) | 0.3 ± 0.01 | 3.8 ± 1.5 | 12.7 (P = 0.07) |
| 11,12- | 1.2 ± 0.8 | 12.6 ± 4.4 (P = 0.03) | 0.09 ± 0.06 | 0.9 ± 0.3 | 10 (P = 0.046) |
| 14,15- | 10.4 ± 0.2 | 24.1 ± 4.2 (P = 0.03) | 0.4 ± 0.01 | 0.8 ± 0.1 | 2 (P = 0.04) |
a
Control values for 5,6- and 14,15-EETs were 30.4 ± 0.8 and 9.6 ± 0.2, respectively, and for 8,9- and 11,12-EETs were not detectable.