Fig. 4.

P450 induction in liver is species-dependent but not sex-dependent. (A) In both male and female mice, hepatic CYP2B10 is significantly induced by both PB and DEX, whereas hepatic CYP3A11 is upregulated by DEX but not PB. Differences in induction between sexes are not statistically significant as determined by Student’s t test (P < 0.05). (B) Hepatic CYP2B10 is induced by both PB and DEX in male mice, but the rat ortholog, CYP2B1/2, is induced only by PB in male rats. CYP3A11 is upregulated in male mice by DEX but not by PB. Conversely, the rat ortholog, CYP3A2, is induced by PB but not by DEX. P450 transcript levels in animals treated with either PB or DEX are presented relative to species-specific vehicle controls. *P < 0.05; **P < 0.01; ***P < 0.001, significantly different from vehicle controls as determined by automated randomization and bootstrapping tests (REST 2009 software).