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Xenobiotic-induced cytotoxicity in LLC-vector and LLC-MDR1-WT cells. LLC-vector and LLC-MDR-WT cells were treated with either doxorubicin (A and B), colchicine (C and D), or paraquat (E and F). Cell viability was tested with xenobiotic alone (square, solid line), or in the presence of P-gp inhibitors GF120918 (triangle, dashed line) or verapamil (circle, dotted line). Compounds were tested in triplicate (n = 3) at each concentration point; data are represented as mean ± S.D.
