TABLE 3.

Population pharmacokinetic analysis of paraquat in FVB wild-type and mdr1a^−/−/1b^−/− mice following a single paraquat oral dose

	FVB Wild-Type (n = 34)				mdr1a−/−/1b−/− (n = 28)
	Estimates	%RSE	95% CI	CV%	Estimates	%RSE	95% CI	CV%
CL/F (l/h)	0.473	5.18	0.425–0.521	—	0.777*	13.3	0.575–0.979	—
V/F (l)	1.77	7.91	1.50–2.04	—	3.36*	14.8	2.39–4.33	—
ka (h−1)	1.81	16.9	1.21–2.41	—	5.60a	—	—	—
IIV-CL/F	0.056	35.1	0.018–0.095	23.7	0.344	32.0	0.128–0.560	58.7
IIV-V/F	0.072	49.6	0.002–0.141	26.8	0.514	24.7	0.265–0.763	71.7
RUV	0.118	23.3	0.064–0.172	34.4	0.133	22.5	0.074–0.192	36.5

IIV, interindividual variability; RUV, residual unexplained variability; RSE, relative standard error; CI, confidence interval.

^aFixed pharmacokinetic estimate from one-compartmental model analysis. *P < 0.05 for parameter estimates between mouse strains.