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. Author manuscript; available in PMC: 2014 Feb 4.
Published in final edited form as: Int J Pharm. 2010 Sep 29;402(0):64–71. doi: 10.1016/j.ijpharm.2010.09.020

Scheme 1.

Scheme 1

Synthesis of PEGylated MPs (PEG1- and PEG2-MPs) from C-MPs. Reagents and conditions: A) TSTU, DMSO, RT, 15 min; B) DAPEG (3.4 kDa), DMSO, RT 24 h; C) EDTA, DMSO, RT, 8 h; D) TSTU, DMSO, RT, 15 min; and E) DAPEG (3.4 kDa), DMSO, RT 24 h.