Table 4.

Summary of geometric mean, geometric mean ratio, and 90% confidence internal (90% CI) of pharmacokinetic parameters between WM and WM + CMF1.

Analyte	Parameters	Geometric mean		GM Ratio, %b	90% CI, %c
		WM  (n = 14)	WM + CMF1  (n = 14)
OA	C max (ng/mL)	62.42	48.81	78.19	60.82–100.51
	AUC0–12 h (ng·h/mL)	129.86	124.76	96.08	88.48–104.33
	12 h Cum. amt. (μg)a	2745.53	2726.98	99.32	85.56–115.30
OC	C max (ng/mL)	526.27	480.59	91.32	84.81–98.33
	AUC0–12 h (ng·h/mL)	4453.91	4067.40	91.32	83.80–99.52
	12 h Cum. amt. (μg)a	71215.61	61224.10	85.97	76.64–96.44
OC/OA	AUC0–12 h ratio	34.30	32.60	95.05	85.64–105.50
	12 h Cum. amt. ratio	25.94	22.45	86.56	76.49–97.94

^a12 h cumulative amount of analyte in urine.

^bGeometric mean ratio of (WM + CMF1)/WM.

^c90% CI criteria of 80%–125% [10].