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Modification reinforcement model (Zhu and Reinberg, 2011). DNA replication results in hemi-methylated daughter DNA strands. UHRF1 recognizes the hemi-methylated DNA and recruits DNMT1 to restore the DNA methylation pattern on the newly-synthesized DNA. The interaction of DNMT1 with G9a, results in posttranslational modifications of the newly deposited histones (top). Furthermore, H3K9me2/3 mark recruits UHRF1 and DNMT1-G9a, thereby facilitating DNA and H3K9 methylation (bottom).
