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. Author manuscript; available in PMC: 2014 Feb 4.
Published in final edited form as: Arch Gen Psychiatry. 2008 Jun;65(6):649–658. doi: 10.1001/archpsyc.65.6.649

Table 1.

Description of data sets. For inclusion in a) the phenotype data set, families needed to have at least two individuals with neuroticism scores and known age, only one of an MZ pair included and b) the linkage analysis data set, families size limited to 2–5 siblings with neuroticism scores, known age and genotype data on > 280 markers.

Australia Netherlands
AU80 AU89 AU99 AU02 AU NL91 NL93 NL97 NL99 NL02 NL AU&NL
a) Phenotype
# families 2017 4253 938 576 4999 1661 2014 1283 1332 2069 3808 8807
# sib-pairs 2033 10513 1709 1589 12772 997 1148 3220 2691 2553 6863 19635
Mean age 33.4 35.1 43.1 40.2 17.7 19.2 26.6 30.9 32.8
Sib-correlations 0.18 0.14 0.274 0.10 0.14 0.25 0.28 0.16 0.20 0.17 0.20 0.16
 Female-female 0.25 0.16 0.314 0.13 0.14 0.25 0.34 0.20 0.19 0.25 0.23 0.17
 Male-male 0.18 0.13 0.304 0.15 0.18 0.27 0.34 0.07 0.18 0.13 0.17 0.18
 Female-Male 0.12 0.12 0.244 0.07 0.11 0.23 0.21 0.18 0.21 0.12 0.19 0.14
b) Linkage analysis
# families 1035 1634 802 306 1945 133 224 410 367 359 564 2509
# individuals with G1 3209 5523 2862 1378 6522 558 834 1533 1405 1376 2030 8552
# full sib-pairs2 1046 2988 1350 912 3870 133 226 825 678 613 1199 5069
 #female-female 427 11191 512 325 1501 47 86 319 268 261 461 3542
 #male-male 168 431 202 154 586 30 48 161 124 106 219 805
Proportion of families
  2 sibs 1.00 0.75 0.75 0.52 0.73 1.00 1.00 0.65 0.69 0.72 0.62
  3 sibs 0.00 0.17 0.19 0.24 0.17 0.00 0.00 0.23 0.22 0.21 0.23
  4+ sibs 0.00 0.08 0.06 0.24 0.10 0.00 0.00 0.12 0.09 0.08 0.12
LOD suggestive3 1.6 1.7 1.7 1.7 1.7 1.5 1.5 1.7 1.7 1.7 1.6 1.7
LOD significant3 2.9 3.0 3.0 3.5 3.1 2.7 2.8 3.1 3.4 3.3 3.1 3.1
ELOD204 1.4 8.0 2.3 1.3 11.9 0.4 0.9 2.0 1.7 1.6 10.0 20.96
1

G =genome scan data;

2

MZ pairs excluded; a small number of families only contributed half-sib pairs;

3

empirical suggestive and significant LOD score thresholds from 1000 gene drop simulation genome scans.

4

Expected LOD of a QTL that accounts for 20% of the phenotypic variance.

5

the high full-sib correlation reflects the ascertainment for inclusion in the Australian 1999 study.

6

ELOD20 for AU&NL ≠ ELOD20 for AU + ELOD20 for NL, because of different heritabilities used.