Table 1.
Description of data sets. For inclusion in a) the phenotype data set, families needed to have at least two individuals with neuroticism scores and known age, only one of an MZ pair included and b) the linkage analysis data set, families size limited to 2–5 siblings with neuroticism scores, known age and genotype data on > 280 markers.
Australia | Netherlands | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AU80 | AU89 | AU99 | AU02 | AU | NL91 | NL93 | NL97 | NL99 | NL02 | NL | AU&NL | |
a) Phenotype | ||||||||||||
# families | 2017 | 4253 | 938 | 576 | 4999 | 1661 | 2014 | 1283 | 1332 | 2069 | 3808 | 8807 |
# sib-pairs | 2033 | 10513 | 1709 | 1589 | 12772 | 997 | 1148 | 3220 | 2691 | 2553 | 6863 | 19635 |
Mean age | 33.4 | 35.1 | 43.1 | 40.2 | 17.7 | 19.2 | 26.6 | 30.9 | 32.8 | |||
Sib-correlations | 0.18 | 0.14 | 0.274 | 0.10 | 0.14 | 0.25 | 0.28 | 0.16 | 0.20 | 0.17 | 0.20 | 0.16 |
Female-female | 0.25 | 0.16 | 0.314 | 0.13 | 0.14 | 0.25 | 0.34 | 0.20 | 0.19 | 0.25 | 0.23 | 0.17 |
Male-male | 0.18 | 0.13 | 0.304 | 0.15 | 0.18 | 0.27 | 0.34 | 0.07 | 0.18 | 0.13 | 0.17 | 0.18 |
Female-Male | 0.12 | 0.12 | 0.244 | 0.07 | 0.11 | 0.23 | 0.21 | 0.18 | 0.21 | 0.12 | 0.19 | 0.14 |
b) Linkage analysis | ||||||||||||
# families | 1035 | 1634 | 802 | 306 | 1945 | 133 | 224 | 410 | 367 | 359 | 564 | 2509 |
# individuals with G1 | 3209 | 5523 | 2862 | 1378 | 6522 | 558 | 834 | 1533 | 1405 | 1376 | 2030 | 8552 |
# full sib-pairs2 | 1046 | 2988 | 1350 | 912 | 3870 | 133 | 226 | 825 | 678 | 613 | 1199 | 5069 |
#female-female | 427 | 11191 | 512 | 325 | 1501 | 47 | 86 | 319 | 268 | 261 | 461 | 3542 |
#male-male | 168 | 431 | 202 | 154 | 586 | 30 | 48 | 161 | 124 | 106 | 219 | 805 |
Proportion of families | ||||||||||||
2 sibs | 1.00 | 0.75 | 0.75 | 0.52 | 0.73 | 1.00 | 1.00 | 0.65 | 0.69 | 0.72 | 0.62 | |
3 sibs | 0.00 | 0.17 | 0.19 | 0.24 | 0.17 | 0.00 | 0.00 | 0.23 | 0.22 | 0.21 | 0.23 | |
4+ sibs | 0.00 | 0.08 | 0.06 | 0.24 | 0.10 | 0.00 | 0.00 | 0.12 | 0.09 | 0.08 | 0.12 | |
LOD suggestive3 | 1.6 | 1.7 | 1.7 | 1.7 | 1.7 | 1.5 | 1.5 | 1.7 | 1.7 | 1.7 | 1.6 | 1.7 |
LOD significant3 | 2.9 | 3.0 | 3.0 | 3.5 | 3.1 | 2.7 | 2.8 | 3.1 | 3.4 | 3.3 | 3.1 | 3.1 |
ELOD204 | 1.4 | 8.0 | 2.3 | 1.3 | 11.9 | 0.4 | 0.9 | 2.0 | 1.7 | 1.6 | 10.0 | 20.96 |
G =genome scan data;
MZ pairs excluded; a small number of families only contributed half-sib pairs;
empirical suggestive and significant LOD score thresholds from 1000 gene drop simulation genome scans.
Expected LOD of a QTL that accounts for 20% of the phenotypic variance.
the high full-sib correlation reflects the ascertainment for inclusion in the Australian 1999 study.
ELOD20 for AU&NL ≠ ELOD20 for AU + ELOD20 for NL, because of different heritabilities used.