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. Author manuscript; available in PMC: 2014 Feb 4.
Published in final edited form as: Arch Gen Psychiatry. 2008 Jun;65(6):649–658. doi: 10.1001/archpsyc.65.6.649

Table 4.

Summary of linkage studies of neuroticism ordered by number of sibpairs measured for neuroticism

a. Country
b. Study Name (if any)
c. Reference
d. Measure of neuroticism.
e. No. of measures if >1		 Ascertainment of base population # sibpairs measured Selection criterion for inclusion in linkage analysis # sibpairs in linkage analysis.
Inter-marker distance.		 Analysis No. linkage peaks identified1
SIG SIGsex SUG SUGsex
  • a

    UK

  • c

    Fullerton et al16

  • d

    EPQ-R

 Community-based sample 34,580 Used neuroticism score to select 2.5% most discordant and 2.5% most concordant, 78%2 response rate 629
10cM 		Visscher-Hopper59 regression 2 3 83 33
  • a

    Australia & Netherlands

  • c

    This paper

    See next 2 rows.

 See next 2 rows 19,635 See next 2 rows 5,424 Merlin-Regress44 0 0 2 1
  • a

    Australia

  • c

    This paper

  • d

    EPR-R/EPQ-R-S/NEO

  • e

    Mean score of up to 4 measures over 22 years

  1. Twin individuals and their families.

  2. Large families with high incidence of smokers

  1. 11,665

  2. 1,107 independent

  1. Although based on an EDAC design in which neuroticism score to select one sib in top/bottom 10%, other sib in top bottom 20%, 91%2 response rate8, the selectively genotyping overall was weak Figure 1a

  2. None

  1. 3,364

  2. 702

    8cM§

 Merlin-Regress 0 0 0 1

  1. Netherlands

  2. NETSAD

  3. This paper

  4. ABV

  5. Mean score of up to 5 measures over 11 years

 Twin individuals and their families 6,863 None. No difference in distribution of neuroticism scores for those with and without genotypes. 1,358
11cM§ 		Merlin-Regress 0 0 3 3

  1. UK

  2. GENESiS

  3. Nash et al10

  4. EPQ-R-S

  5. Means score of up to 2 (78% with 2 measures) 6 months apart.

 Community-based sample 4,824 Most informative 10%, Response rate 65%2 297
9 cM		 Merlin-Regress 0 1 04 2
  • a

    Ireland & Northern Ireland

  • c

    Kuo et al22

  • d

    EPQ-R-S

 Sibships concordant for alcohol dependence 714 None 714
4cM		 Merlin-Regress 1 4 25 45
  • a

    New Zealand

  • c

    Neale et al21

  • d

    EPQ-R-S

 Sibships concordant for nicotine dependence 201 None 201
10cM 		Merlin-Regress 0 N/A 5 N/A
1

Exceed Lander and Kruglyak12 empirical thresholds for significant (SIG) or suggestive (SUG) linkage: One linkage test statistic of observed magnitude or greater expected by chance every twenty genome scans (SIG) or each genome scan (SUG). Sex specific linkage peaks, SIGsex, SUGsex.

2

Response rates are for individuals and reflect the success of the selection criterion for entry into the linkage study; response rate for sibpairs are expected to be the square of this number.

3

Estimated from their Figure 2 assuming threshold of −logP = 2.5.

4

One suggestive region identified but listed as significant sex specific region.

5

Estimated as those with LOD >1 (as empirical threshold for SIG was 1.29).

§

Calculated as the average distance between markers genotyped in both members of sib pairs, which is likely to be higher than the average distance between markers reported for the other studies.

estimated from number of markers