Fig. 2.
Hth/Exd repress Senseless in DRA R8 cells. (A) Ectopic VP16:Exd led to loss of Rh3 expression (red) in the R8 layer of DRA ommatidia (lower half of dashed box). (B) Expression of Rh6 (green) was expanded into the DRA (dashed box). (C) Hth expression (green) was unaffected by LGMR>VP16:Exd (white arrows, inset). (D) Sens expression (pink) was not affected by LGMR>VP16:Exd (green). (E) Co-expression of Sens (green) and Exd (red) was observed in all R8 cells of LGMR>VP16:Exd flies, including the dorsalmost rows. The endogenous DRA could no longer be labeled, due to loss of appropriate markers. (F) Identical phenotype obtained by overexpression of dominant-negative Homothorax (LGMR>hthHM).