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. 2014 Feb 15;141(4):918–928. doi: 10.1242/dev.103127

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© 2014. Published by The Company of Biologists Ltd

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Fig. 5. — Hth/Exd function in the DRA depends on inner photoreceptor specification by Spalt. (A) Co-expression of Hth (green) and Spalt (red) in the pupal DRA (dashed line). (B) Activated Ras (sev-Ras^Val12) generated extra R7 cells throughout the retina, marked by Spalt (red) and Hth (green), when located in the DRA. (C) Overexpression of Salm (red) did not induce extra inner photoreceptors in the DRA (marked by Hth, green). (D) Hth (green) was lost in homozygous salr,salm (-/-) clones (dashed line), marked by the absence of Armadillo-lacZ (red) (D′). (E-H) Hth gain of function requires Spalt. rh3-lacZ (E) was lost in salm,salr (-/-) mutant eyes (F), and expanded to all inner photoreceptors when Hth was ectopically expressed (G). Overexpression of Hth in salm,salr (-/-) mutants resulted in loss of rh3-lacZ (H).