Table 5.

Hypothesized mechanisms linking obesity and asthma

Hypothesized mechanisms linking obesity and asthma	Selected references
Mechanical effects of obesity on airway physiology	46,47
Shared inflammatory signaling abnormalities	48–56
Shared alterations in oxidative/antioxidant signaling	57,58
Effect of adipokines on airway biology and immune regulation	52,64–67
Altered metabolic signaling	59–63
Comorbid conditions, including sleep-disordered breathing and gastroesophageal reflux disease	36,37,68–73