Figure 1.

Behavioral profile of olfactory bulbectomy (OBx) Mice. (A) Olfactory bulbectomy mice step-down quicker than sham-operated controls. (B) Olfactory bulbectomy mice have a higher duration of immobility in the tail-suspension test indicative of higher levels of behavioral depression. Olfactory bulbectomy mice show elevated levels of anxiety-like behavior in an open field test as shown by (C) hyperlocomotion, (D) decreased distance travelled in the anxiety-inducing center zone, and (E) increased rearing. (F) Olfactory bulbectomy does not affect general measures of motor activity. (*P < 0.05 vs sham controls). Data are presented as mean ± SEM.