Table 2.

Summary of studies examining the interaction between life stress and brain-derived neurotrophic factor ( BDNF ) Val66Met in depression

Source	N	Females,%	Age at study assessment (Mean or range)	Ancestry	Study design	Stressor	Life stress assessment	Outcome	Averaged one-sided P value
Kaufman et al., 2006 [79]	194	51	9.3 years	Mixed	Cross-sectional	Childhood adversity	Children taken into care	Depressive symptoms	0.6765
Kim et al., 2007 [43]	732	59	65 years and over	East Asian	Cross-sectional	Stressful life events	Researcher-administered questionnaire	Depression diagnosis	0.000315
Wichers et al., 2008 [73]	464	100	18 to 46 years	European	Longitudinal twin study	Childhood adversity	Questionnaire	Depressive symptoms	0.009
Aguilera et al., 2009 [66]	470	55	22.9 years	European	Cross-sectional	Childhood adversity	Questionnaire	Depressive symptoms	0.637
Bukh et al., 2009 [82]	290	66	38.5 years (median)	European	Case only	Stressful life events	Interview	Depression onset	0.004
Gatt et al., 2009 [88]	374	51	36.2 years	European	Cross-sectional	Childhood adversity	Questionnaire	Depressive symptoms	0.272
Hosang et al., 2010 [75]	1,085	62	37.83 years	European	Case–control	Stressful life events	Researcher-administered questionnaire	Bipolar disorder relapse	0.02
Lavebratt et al., 2010 [68]	950	58	20 to 64 years	European	Longitudinal survey	Childhood adversity and Stressful life events	Questionnaire	Depressive diagnosis	0.5
Nederhof et al., 2010 [80]	1,096	53	16.13 years	European	Longitudinal study	Childhood adversity	Questionnaires and interviews	Depressive symptoms	0.3525
Carver et al., 2011 [76]	133	74	18.71 years	Mixed	Cross-sectional	Childhood adversity	Questionnaire	Depression diagnosis	0.01
Elzinga et al., 2011 [81]	1,435	69	42.2 years	European	Case only	Childhood adversity and stressful life events	Interview	Depression diagnosis and symptom severity	0.4325
Juhasz et al., 2011 [74]	1,269	70	34.04 years	Caucasian	Cross-sectional	Childhood adversity and stressful life events	Questionnaire	Depression diagnosis	0.13165
Chen et al., 2012 [69]a	780	51	13.6 years	Han Chinese	Longitudinal twin study	Stressful life events	Questionnaire	Depressive symptoms	0.9875
Grabe et al., 2012 [70]a	2,035	53	55.6 years	Caucasian	Case only	Childhood adversity	Questionnaire	Depressive symptoms	0.785
Herbert et al., 2012 [83]	279	100	36.8 years	Caucasian	Longitudinal study	Stressful life events	Interview	Depression diagnosis	0.0935
Perea et al., 2012 [77]	302	50	18 years	Mixed (Columbian population)	Cross-sectional	Childhood adversity and stressful life events	Questionnaire	Depressive symptoms	0.01725
Quinn et al., 2012 [65]	240	59	40.01 years	Unknown	Cross-sectional	Childhood adversity	Questionnaire	Melancholic subtype of depression diagnosis	0.5
Caldwell et al., 2013 [71]a	124	66	21.97 years	Mixed	Cross-sectional	Childhood adversity	Questionnaire	Depressive symptoms	0.8705
Comasco et al., 2013 [67]	1,393	50	17 to 18 years	European	Cross-sectional	Childhood adversity	Questionnaire	Depressive symptoms	0.251
La Greca et al., 2013 [78]	116	54	8.85 years	Mixed	Cross-sectional	Childhood adversity	Questionnaire	Depressive symptoms	0.167833
Jiang et al., 2013 [89]a	238	73	61.7 years	Caucasians	Cross-sectional	Stressful life events	Carer of person with dementia	Depressive symptoms	0.9805
Brown et al., 2013 [85]	234	100	37 years	Caucasian	Longitudinal study	Childhood adversity and stressful life events	Interview	Depressive episode onset	0.431
Total	14,233
Average sample size	647								0.03

^aTested Val recessive model.