Fig. (3).

Schematic representation of ErbBs/EGFR(s) signaling pathways. Ligand binding to ectodomain of EGFR(s) leads to dimerization of the receptor and subsequent activation of tyrosine kinase domain. Complexity of ErbB signaling is regulated by ligand specific binding, leading to different combinations of homo/ -hetero dimerization of the receptors. Depending on the type of homo/-hetero dimer formed, a distinct intracellular pathway is activated. These pathways are involved in several processes of cellular homeostasis. PI3K: Phospholinositide-3-Kinase; Akt: phospho kinase B (PKB); JAK: Janus Kinase; STAT: Signal Transducer and Activator of Transcription; ERK: Extracellular Signal Regulated Protein Kinase; MAPK: Mitogen Activated Protein Kinase.