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. 2014 Jan 1;141(1):199–208. doi: 10.1242/dev.100206

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Loss of chromosome cohesion in aged eggs correlates with less SGO2. (A) Nineteen sister chromatid pairs (dyads) and two single chromatids (boxed, 5 and 5′; inset, zoomed) in an aged metII mouse egg. Numbering done to aid counting. (B) PSSC rate in young versus aged fixed eggs (Fisher’s exact test). (C) Scatter plot demonstrating association of reduced centromeric SGO2 intensity with increasing iKT distance (measured as shown in inset, Spearman correlation). (D) Centromeric SGO2 intensity (mean and s.e.m.) at one kinetochore of a sister chromatid pair or single chromatid, with representative images shown on top (Mann-Whitney U). Scale bars: 1 μm in C,D; 10 μm in A. ACA, anti-centromeric antibodies.