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. 2014 Jan 1;141(1):199–208. doi: 10.1242/dev.100206

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Generation of single chromatids in aged eggs during MII. (A) Loss and then gain of the H2B chromatin and CENPC kinetochore signals associated with MI exit, interkinesis and establishment of a metII spindle. (B) Percentage of metII eggs with single chromatids is higher in aged oocytes (Fisher’s exact test). (C) Timing of separation of a dyad into single chromatids in oocytes from aged mice. (D) Premature separation of a sister chromatid pair (dyad) following recondensation, boxed and expanded in inset. (E) Oscillatory behaviour of single chromatids during metII arrest. Representative of 26 aged oocytes examined. All times are relative to anaphase onset. Scale bars: 10 μm.