Table 1.
Relationship between Glucose Levels and Stem Cells Function
| Glucose concentration | Stem cell type | Human / Rat | Effects | Ref. |
|---|---|---|---|---|
| High level glucose | Non adherent bone- marrow-derived MSC | Rat | Negative effect on SC colony formation and differentiation | 18 |
| Low level glucose | Adipose-derived MSC | Human | Positive effect on survival and biological behaviors | 19 |
| High level glucose | MSC | Diabetic mice | Induce premature senescence and apoptosis, reduce colony forming activity | 22 |
| High level glucose | MSC | Human | Stimulate proliferation and osteogenic differentiation | 23 |
| High level glucose | Adult vascular stem/progenitor cell | Human | Reduce growth, alter differentiation potential | 24 |
| High level glucose | ESC | mice | Increase SC growth | 27 |
Abbreviations: MSC, Mesenchymal stem cell. SC, Stem cell. ESC, Embryonic stem cell