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. Author manuscript; available in PMC: 2014 Feb 4.
Published in final edited form as: Circ Res. 2008 Feb 21;102(7):823–830. doi: 10.1161/CIRCRESAHA.107.165332

Figure 4.

Figure 4

Identification of RepD in the human IL-1α gene. A, Schematic representation of the human IL-1α gene promoter and contiguous 270 bp of 3′ sequence. The nucleotide sequence of the RepD-A sequence is shown. B, Luciferase reporter plasmids regulated by the human IL-1α gene promoter plus the contiguous 270 bp of 3′ sequence, or by the IL-1α promoter alone, were transfected into human aortic endothelial cells. Production of the luciferase reporter gene measured 36 hours later revealed that the additional 270 bp containing the RepD-A sequence suppressed luciferase reporter gene activation. The bar graph reflects the mean±SEM for triplicate samples and is representative of 3 experiments.