Table 5.
In vitro cytotoxicity (IC50 values) of the napyradiomycins 1–4 and related napyradiomycin congeners against HCT-116 colon carcinoma. The 95% confidence interval data are shown to the right. For several compounds the 95th percent confidence interval could not be established due to excessively high or low IC50 values - these are marked NA(not accessable).
| Compound | IC50 values | 95% CI |
|---|---|---|
| Napyradiomycin CNQ525.510B (1) | 17 μM | 10.6 – 26.0 μM |
| Napyradiomycin CNQ525.538 (2) | 6 μM | 3.5 – 10.5 μM |
| Napyradiomycin CNQ525.554 (3) | >100 μM | NA |
| Napyradiomycin CNQ525.600 (4) | 49 μM | 16.3 – 90.9 μM |
| Napyradiomycin B1 | 2 μM | 0.8 – 7.4 μM |
| Napyradiomycin B3 | 3 μM | 1.0 – 5.0 μM |
| Napyradiomycin B4 | 10 μM | 2.8 – 32.6 μM |
| A80915A | 3 μM | 1.0 – 9.5 μM |
| A80915B | <1 μM | NA |
| A80915C | 15 μM | 7.4 – 28.8 μM |
| A80915D | <1 μM | NA |
| CNQ525.510A | >100 μM | NA |
| CNQ525.512 | >100 μM | NA |
| etoposide control | 1 μM | 0.7 – 2.2 μM |