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. Author manuscript; available in PMC: 2014 Feb 4.

Published in final edited form as: J Med Chem. 2008 Jul 22;51(15):4370–4373. doi: 10.1021/jm8002894

Table 2. In Vitro Antiproliferative Activity of Compounds 1 – 11 against Pancreatic Cancer Cell Lines.

	IC₅₀ (μM)

compd	BxPC-3	HupT3	Mia Paca-2	Panc 04.03	SU.86.86	HMEC^a	HPDE6c7^a
1	7	0.4	1	1.5	1	^b	^b
2	28	5	4	5	5	^b	^b
3	1	0.8	0.7	1	1	7	1.5
4	36	14	8	14	22	^b	^b
5	0.7	0.1	0.1	0.9	0.2	<1	0.2
6	38	37	25	>50	25	^b	^b
7	1	0.3	0.1	0.1	0.6	<1	0.5
8	25	10	12	16	24	^b	^b
9	0.8	0.2	0.1	0.1	0.8	<1	0.4
10	33	7	10	17	11	^b	^b
11	6	1	0.9	4	1	^b	^b
SAHA	5	0.8	1	1	1	1.3	1.3

^a

Normal cell lines.

^b

Not detected.