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. 2013 Sep 5;2(4):e26276. doi: 10.4161/worm.26276

graphic file with name worm-2-e26276-g4.jpg

Figure 4. Artificial, external Wnt cue can orient cell division axis and induce asymmetric cell fate in mammalian embryonic stem cell. Beads loaded with active Wnt proteins positioned next to a cell induces: (1) orientation of the cell division axis of that cell toward the Wnt source; (2) asymmetric accumulation of β-catenin in the cell proximal to the Wnt source; and (3) two different cell fates in the daughter cells.