Table 3.
Clinical and demographic characteristics in patients with different grades of tertiary lymphoid organs at the time of biopsy
| Characteristic | Tertiary Lymphoid Organ Grade | P Value | ||
|---|---|---|---|---|
| 0 (n=93) | 1 (n=33) | 2 (n=26) | ||
| Male sex | 51.6 | 57.6 | 61.5 | 0.33 |
| Age≥50 (yr) | 7.5 | 21.2 | 15.4 | 0.11 |
| Serum creatinine≥1.2 (mg/dl) | 20.5 | 36.4 | 46.2 | 0.01 |
| Serum uric acid≥7.0 (mg/dl) | 16.5 | 34.5 | 26.0 | 0.16 |
| Proteinuria≥2.0 (g/24 h) | 31.2 | 50.0 | 64.7 | 0.003 |
| Erythrocyturia≥3+a | 50.5 | 42.4 | 61.5 | 0.54 |
| BP grade≥2b | 5.4 | 15.6 | 19.2 | 0.01 |
| Oxford classificationc | ||||
| M1 | 54.8 | 72.7 | 84.6 | 0.003 |
| S1 | 38.7 | 45.5 | 61.5 | 0.04 |
| E1 | 10.8 | 6.1 | 7.7 | 0.51 |
| T1 and T2 | 14.0 | 27.6 | 70.6 | <0.001 |
| Marked global glomerulosclerosisd | 28.1 | 38.1 | 50.0 | 0.11 |
| Presence of crescentse | 12.9 | 28.6 | 35.3 | 0.01 |
| Marked arterial wall thickening | 8.6 | 21.2 | 50.0 | <0.001 |
| Presence of arterial hyalinosis | 29.0 | 42.4 | 57.7 | 0.01 |
Data are presented as percentages. Comparisons between groups were performed by chi-squared tests. RBC, red blood cell; HPF, high-power cortical field; SBP systolic BP; DBP, diastolic BP.
The severity of erythrocyturia was defined as follows: 3 ≤ RBC ≤ 5/HPF was defined as 1+; 5 < RBC ≤ 20/HPF as 2+; 20 < RBC ≤ 50 RBC/HPF as 3+; and >50 RBC/HPF was defined as 4+.
BP was graded in three groups: 0, SBP < 140 mmHg and DBP < 90 mmHg; 1, 160 mmHg > SBP ≥ 140 mmHg or 100 mmHg > DBP ≥ 90 mmHg; and 2, SBP ≥ 160 mmHg or DBP ≥ 100 mmHg.
Pathologic features were scored using the Oxford classification (8,9). M1 was defined by the presence of >3 cells in the most cellular mesangial area, but not adjacent to the vascular stalk, on >50% of the glomeruli. S1 was defined by the presence of tuft adhesion and segmental sclerosis but not global sclerosis. E1 was defined by the presence of an increased number of cells within the capillary lumina causing narrowing. The percentage of a cortical area damaged by interstitial fibrosis or tubular atrophy was defined as T0 (≤25%), T1 (26%–50%), or T2 (>50%).
The severity of global glomerulosclerosis and arterial wall thickening was divided into three groups: normal, mild, and marked.
Crescents and arterial hyalinosis were scored as present or absent.