Table 2.

Annual rate of change in serum albumin (g/dl) in various clinical strata

Stratum	Estimate Slopea	95% Confidence Interval	P Value Slope	P Interaction Term
Age<66.8 yr	−0.05	−0.06 to −0.03	<0.001	Age×time
Age≥66.8 yr	−0.12	−0.14 to −0.09	<0.001	<0.001
Men	−0.09	−0.11 to −0.07	<0.001	Sex×time
Women	−0.06	−0.08 to −0.03	<0.001	0.05
DM	−0.11	−0.14 to −0.08	<0.001	DM×time
No DM	−0.07	−0.08 to −0.05	<0.001	0.002
CVD	−0.09	−0.12 to −0.07	<0.001	CVD×time
No CVD	−0.07	−0.09 to −0.05	<0.001	0.20
RKF	−0.08	−0.10 to −0.06	<0.001	RKF×time
No RKF	−0.07	−0.09 to −0.05	<0.001	0.81
Vintage below median	−0.07	−0.10 to −0.05	<0.001	Vintage×time
Vintage at and above median	−0.08	−0.10 to −0.06	<0.001	0.72

All analyses on strata were adjusted for age, sex, dialysis vintage, randomized group (excluding the conventional risk factor of the stratum under study), and presence of DM, CVD, and RKF. Estimates in this table may differ slightly from estimates in the text of the Results, because estimates in this table are derived from models performed in the subgroups separately. DM, diabetes mellitus; CVD, cardiovascular disease; RKF, residual kidney function.

^aEstimate slope indicates mean longitudinal change per year in serum albumin levels associated with the presence or absence of the conventional risk factor.