Table 5.

Annual rate of change in LnIL-6 [Ln(pg/ml)] in various clinical strata

Stratum	Estimate Slopea	95% Confidence Interval	P Value Slope	P Value Interaction Term
Age<65.9	0.07	−0.01 to 0.14	0.07	Age×time
Age≥65.9	0.09	0.03 to 0.16	0.01	0.21
Men	0.13	0.07 to 0.20	<0.001	Sex×time
Women	0.02	−0.06 to 0.09	0.63	0.04
DM	0.16	0.07 to 0.26	0.001	DM×time
No DM	0.07	0.01 to 0.12	0.03	0.12
CVD	0.11	0.04 to 0.18	0.002	CVD×time
No CVD	0.07	0.001 to 0.14	0.05	0.58
RKF	0.08	0.02 to 0.14	0.01
No RKF	0.10	0.02 to 0.18	0.02
No RKF hemodialysis	0.19	0.08 to 0.30	<0.001	0.09b
No RKF hemodiafiltration	−0.02	−0.15 to 0.10	0.69	0.16b
Vintage below median	0.09	0.02 to 0.16	0.01	Vintage×time
Vintage at and above median	0.09	0.02 to 0.16	0.01	0.70

All analyses on strata were adjusted for age, sex, dialysis vintage, allocated treatment (excluding the conventional risk factor of the stratum under study), and presence of DM, CVD, and RKF. Estimates in this table may differ slightly from estimates in the text of the Results, because estimates in this table are derived from models performed in the subgroups separately. LnIL-6, natural logarithm of IL-6.

^aEstimate slope indicates the mean longitudinal change per year in LnIL-6 levels associated with the presence or absence of the conventional risk factor, the percent change per year calculated by e^ΔLnIL6.

^bVersus RKF (no difference hemodialysis and hemodiafiltration).