Table 5.

Predictive ability of urine neutrophil gelatinase-associated lipocalin NGAL for dialysis requirement and/or death in pediatric studies

Study, Year	Setting	Endpoint Event	Timing of Urine Collection	ROC Area	Cutoff (ng/ml)	Sensitivity	Specificity	Positive LR	Negative LR	Diagnostic OR
Trachtman et al., 2006	34 children with diarrhea-associated hemolytic-uremic syndrome	RRT (n=10)	Day of diagnosis		200	0.90	0.54	1.96	0.18	10.89
Bennett et al., 2007	194 children with cardiac surgery	RRT (n=4)	Within 2 h of bypass	0.86	150
			Within 4 h of bypass	0.80
			Within 6 h of bypass	0.90
		In-hospital death (n=3)	Within 2 h of bypass	0.91	150
			Within 4 h of bypass	0.81
			Within 6 h of bypass	0.67
Parikh et al., 2011	311 children with cardiac surgery	Doubling of sCr (n=53) or RRT (n=5)	Within 6 h of initiation of bypass (median, 30 min of ICU admission)	0.71	72	0.42	0.85	2.8	0.68	4.12

LR, likelihood ratio; OR, odds ratio, RRT, renal replacement therapy; sCr, serum creatinine; ICU, intensive care unit.