Table 4.
Factors associated with nonadherence of CKD-related medications (1602 medications in 477 patients)
| Risk Factor | OR (95% CI) for Nonfull Adherence in Past 7 Days | P Value |
|---|---|---|
| Medications currently taking (n) | ||
| 1–2 | 1 (reference) | |
| 3–4 | 0.82 (0.47 to 1.43) | 0.49 |
| ≥5 | 0.63 (0.38 to 1.06) | 0.08 |
| Dosing frequency (times/d) | ||
| <1 | 0.72 (0.49 to 1.05) | 0.09 |
| 1 | 1 (reference) | |
| 2 | 1.18 (0.90 to 1.55) | 0.22 |
| >2 | 1.70 (1.25 to 2.29) | <0.001 |
| Glomerular CKD | 0.75 (0.43 to 1.32) | 0.32 |
| Age (per 1-yr increase) | 1.09 (1.03 to 1.15) | 0.004 |
| Male versus female | 0.99 (0.65 to 1.50) | 0.95 |
| Race | ||
| Caucasian | 1 (reference) | |
| African American | 0.53 (0.30 to 0.92) | 0.02 |
| Other/mixed | 0.37 (0.18 to 0.77) | 0.01 |
| Annual household income<$36,000 | 1.20 (0.79 to 1.82) | 0.39 |
| CKD duration (per 1 yr) | 0.98 (0.93 to 1.03) | 0.46 |
Restricted to CKD-related medications with available adherence and dosing frequency. Analysis evaluates nonadherence of unique reported medications, not medication groups as in earlier analyses. All estimates are adjusted for the variables shown in the table. OR, odds ratio.