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. 2013 Dec 5;9(2):344–353. doi: 10.2215/CJN.05840513

Figure 1.

Figure 1.

Mineral and hormone values according to estimated GFR at 10-ml/min per 1.73 m2 intervals in children with CKD. Median concentrations of (A) serum corrected–calcium, phosphorus, and immunoreactive parathyroid hormone (iPTH) and (B) serum 25-hydroxyvitamin D (25OHD) (ng/ml), 1,25-dihyroxyvitamin D [1,25(OH)2D] (pg/ml), and plasma fibroblast growth factor 23 (FGF23). Higher levels of serum iPTH precede changes in serum calcium and phosphorus. Higher levels of plasma FGF23 precede changes in 25OHD and 1,25(OH)2D. *P<0.05 versus the reference GFR group of ≥70 ml/min per 1.73 m2 using Kruskal–Wallis ANOVA. The dotted lines indicate the upper limit of normal for PTH (65 pg/ml) and FGF23 (101 RU/ml). The number of participants in each GFR group is indicated below each figure. Additional data are provided in Supplemental Table 1.