Table 1.
Ultrasound criteria for diagnosis and exclusion of autosomal dominant polycystic kidney disease
| PKD1 | PKD2 | Unknown ADPKD Gene Type |
| Diagnosis | ||
| 15–29 yr | ||
| ≥3 cystsa | ||
| PPV: 100% | PPV: 100% | PPV: 100% |
| Sens: 94.3% | Sens: 69.5% | Sens: 81.7% |
| 30–39 yr | ||
| ≥3 cystsa | ||
| PPV: 100% | PPV: 100% | PPV: 100% |
| Sens: 96.6% | Sens: 94.9% | Sens: 95.5% |
| 40–59 yr | ||
| ≥2 cysts (in each kidney) | ||
| PPV: 100% | PPV: 100% | PPV: 100% |
| Sens: 92.6% | Sens: 88.8% | Sens: 90% |
| Exclusion | ||
| 15–29 yr | ||
| ≥1 cysta | ||
| NPV: 99.1% | NPV: 83.5% | NPV 90.8% |
| Spec: 97.6% | Spec: 96.6% | Spec: 97.1% |
| 30–39 yr | ||
| ≥1 cysta | ||
| NPV: 100% | NPV: 96.8% | NPV 98.3% |
| Spec: 96% | Spec: 93.8% | Spec: 94.8% |
| 40–59 yr | ||
| ≥1 cysta | ||
| NPV: 100% | NPV: 100% | NPV 100% |
| Spec: 93.9% | Spec: 93.7% | Spec: 93.9% |
All values presented are mean estimates. PKD1, polycystic kidney disease 1; PKD2, polycystic kidney disease 2; ADPKD, autosomal-dominant polycystic kidney disease; PPV, positive predictive value; Sens, sensitivity; NPV, negative predictive value; Spec, specificity. Adopted from reference 55, with permission.
a
Unilateral or bilateral.