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. 2014 Jan 27;21(1):8. doi: 10.1186/1423-0127-21-8

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Copyright © 2014 Wu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fructose upregulates the expression of ketohexokinase and glucose transporters in the N2A cells. Cellular levels of pyruvate (A) and 2-deoxyglucose 6-phosphate (2-DG6P) (E), or representative gels (inset) and densitometric analysis of results from Western blot showing changes in expression of KHK (B), GluT2 (C) or GluT5 (D), examined at 72 hours after the administration of different concentrations of fructose (0, 12.5, 25, or 50 μM) to the N2a cells. Values are mean ± SEM of quadruplicate analyses. *P < 0.05, **P < 0.01 versus control (0 μM fructose) group in the post hoc Tukey’s multiple range test.