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Silencing of PKARIα in HL-1 cells induces RSK1-mediated apoptosis. (A) 48 hours after transfection with mutant (Mut) or Wt siRNA against PKARIα, HL-1 cells were serum starved and incubated with or without SL0101 (50 μM) for 24 hours. Cell lysates were subjected to Western analysis. (B) Quantitative data from Western blots of four different experiments normalized for actin (loading control). Data shown are means ± S.E.M. *P < 0.05. Ctr, control.
